Doribac:

Doribac is a medicine which can perform skin tissue damage or infection  to the reaper. 

Background: GET PREMIUM More Accurate 10X Faster No Ads Priority Support Unlimited Sessions 25,000 Words Limit Bacterial skin and soft tissue infections (SSTIs) are traditionally widely used for treatment with beta-lactam antibiotics or macrolides. However, experts are still debating whether Staphylococcus and Streptococcus species are still working because of their growing resistance. As a result, physicians have begun using broad-spectrum beta-lactam (e.g., third-generation cephalosporins) or fluoroquinolones for the treatment of SSTI in the belief that they may produce better results, with little evidence of this approach.  Falagas and colleagues conducted a meta-analysis of the study comparing beta-lactams with fluoro-quinolones in empirical treatment of SSTI is a huge milestone.

Composition: Doribac® 250 Capsules: Each capsule contains the equivalent amount of fluoxetine 250 mg fluoxetine sodium BP and it produces penicillinase. Doribac® 500 Capsules: Each capsule contains Flucloxacillin Sodium BP equivalent Flucloxacillin 500 mg and works by disrupting the bacterial cell wall. Doribac® PFS: Each 5 ml contains – Flucloxacillin Sodium BP equivalent to Flucloxacillin 125mg 

PHARMACOLOGY : Flucloxacillin is isoxazolyl penicillin of the beta-lactam group of antibiotics which exerts a bactericidal effect upon many gram-positive organism including beta-lactamase-producing staphylococcus and streptococci.It is not active against methicillin-resistant Staphylococcus. 

INDICATIONS: Flucloxacillin is indicated for the treatment of Gram-positive organism infections, including beta-lactamase-producing infections caused by Staphylococcus aureus, including beta-lactamase bacteria. Common hints include: What diseases it is used for: Causes of skin problems such as boils, abscesses, carbuncles, furunculosis, cellulitis; Infected skin conditions, such as ulcers, eczema, and acne; Infected wounds, infected burns, skin grafts, and impetigo protection or in a word skin and soft tissue infections. 

RESPIRATORY TRACT INFECTIONS: pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy, otitis media, and external. Other infections caused by fluoxetine-sensitive organisms include osteomyelitis, enteritis, meningitis, septicemia, endocarditis, and urinary tract infections known as UTIs. Flucloxacillin is indicated for use during major surgeries as a prophylactic agent or to remove bad substances from the body where appropriate, for example, cardiothoracic and orthopedic surgery. 

DOSAGE AND ADMINISTRATION: Oral doses should be administered half to one hour before meals. Use for adult dosage: 250 mg four times daily should not be more than a tick. Rules for use in severe infections: Do not use the dose twice, otherwise the disease will not be prevented. In osteomyelitis and endocarditis: up to 8 grams per day and divided doses are used for 6 to 8 hours, and the same is true of secondary bacterial infections in chickenpox. Flucloxacillin 500 mg 6 hourly should be prescribed. For Children: The usual dose for children of 1-3 year are 1/2-1 teaspoonful (2.5-5 ml) of Doribac® Suspension 4 times daily and Children of 3-10 years: 1-2 teaspoonful (5-10 ml) Doribac® Suspension 4 times daily for 7-10 days according to severity of infections. DOSE 

ADJUSTMENT IN RENAL IMPAIRMENT: As common with other penicillins, Flucloxacillin usage in patients with renal impairment does not usually require dosage reduction. However, in severe renal impairment conditions (creatinine clearance <10 ml / min) dose reduction or increasing dose interval should be considered to have a good effect on the kidneys. Flucloxacillin is not significantly removed by dialysis and hence no supplementary dosage needs to be administered either during or at the end of the dialysis period. 

SSTI
SSTI

SIDE EFFECTS: Side effects as with other penicillin, are uncommon and mainly of a mild and transitory nature. Gastrointestinal upsets (e.g. nausea, diarrhea) and skin rashes have been reported. If skin rash occurs, treatment should be discontinued. 

CONTRAINDICATIONS : Flucloxacillin is contraindicated in patients with known hypersensitivity to Penicillin 

PRECAUTION: Flucloxacillin should be given with caution to patients with a history of allergy, especially to drugs. Before initiating therapy with Flucloxacillin, careful inquiry should be made concerning previous hypersensitivity reactions to B lactams. 

USE IN PREGNANCY AND LACTATION: The use of Flucloxacillin in pregnancy should be reserved for cases considered essential by the clinician. Use of the drug in the second and third trimesters may result in the sensitization of the fetus. During lactation, trace quantities of penicillins can be detected in breast milk. 

OVERDOSAGE: Problems of overdosage with Flucloxacillin are unlikely to occur, If encountered they may be symptomatic. 

DRUG INTERACTIONS: The administration of Probenecid with Flucloxacillin results in higher serum peak concentrations and prolongs the time that therapeutic concentrations of Flucloxacillin are achieved in serum. Physical incompatibility and/or loss of activity of Flucloxacillin in solution has been reported when given with Gentamycin sulfate, Streptomycin sulfate, Vitamin mixtures. Flucloxacillin should not be added to intravenous lipids, blood products, and protein hydrolysates or other proteinaceous fluids. 

STORAGE: Store in a cool (Below 30° C. Temp. ) and dry place, protected from light. Keep out of reach of children. COMMERCIAL PACK: Doribac® 250 Capsule : Each box contains -7×4’s capsule in Alu-Alu blister pack. Doribac® 500 Capsule : Each box contains -7×4’s capsule in Alu-Alu blister pack. Doribac® PFS : Each bottle contains -100 ml PFS with measuring Cup.

Manufactured by: Apex Pharma Ltd. Shafipur, Kaliakair, Gazipur. For CONCORD Pharmaceuticals Ltd. S-18, BSCIC Industrial Area, Kanchpur, Sonargaon, Narayanganj, Bangladesh.

After tutorial Kidney Disease Treatment Guidelines – Fenadin.

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